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The concomitant use of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors may possibly cause a rise in methadone plasma concentrations, which could bring about perhaps deadly respiratory depression. Furthermore, discontinuation of concomitantly utilised cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers can also cause an increase

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